What is the measurement of sperm oxidation-reduction potential?

It is a test that calculates the balance between the total oxidative and reductive activity in the sperm. This way, it is determined if there is oxidative stress in the sperm. Up to 80% of the causes of male infertility are related to oxidative stress.

What is oxidative stress?

Oxidative stress is a condition resulting from an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant mechanisms responsible for neutralizing and removing them. While small amounts of ROS are necessary for the normal functioning of sperm, increased amounts negatively affect their quality and fertilizing ability.

Excessive ROS and their metabolites can damage the sperm's DNA, lipids, and proteins, disrupt motility and morphology, and ultimately lead to cell death.

The production of ROS is influenced by both internal and external factors. Environmental toxins (such as chemicals, air pollution, and radiation), lifestyle choices (like smoking, alcohol consumption, and obesity), age, and stress are key external contributors. Internal factors include urogenital inflammations, such as those caused by varicocele, infections, and systemic conditions like diabetes.

Testing for oxidative stress in seminal fluid is among the latest recommendations of the European Society of Human Reproduction and Embryology (ESHRE) for diagnosing male infertility.

Why is this examination important?

In up to 40% of men with fertility issues, sperm analysis alone may not reveal the underlying cause of infertility.

The MiOXSYS system, designed to complement standard sperm analysis, helps determine whether oxidative stress is contributing to infertility. The test provides immediate results, allowing for prompt treatment and management by a clinical doctor.

How is it performed?

For the examination, a semen sample is required after 2-3 days of abstinence from ejaculation. The measurement of static oxidation-reduction potential (sORP) is conducted using the MiOXSYS system, which employs electrochemical technology to measure the electron transfer to all known and unknown oxidants and reductants (antioxidants) in the sperm. The following categories are distinguished:


<1.38mV/ml sORP		sperm in redox balance
>1.38mV/ml sORP		sperm in a state of oxidative stress

Who should undergo this test?

This examination is recommended for all men over the age of 40 as part of prenatal screening, as well as for men who:

Lead a lifestyle with potential risks (smoking, poor diet, lack of exercise, or excessive exercise)
Unexplained infertility
Have varicocele
Show low sperm parameters
Have reproductive system infections
Have faced recurrent miscarriages or failed assisted reproduction attempts